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The steady-state plasma concentrations of fluoxetine and norfluoxetine increased by about 18 and 36 , respectively, and concentrations of paroxetine decreased by about 27 .

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the efficacy of paroxetine in the treatment of major depressive disorder, social anxiety disorder, obsessive compulsive disorder ocd , panic disorder pd , and generalized anxiety disorder gad is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin 5-hydroxy-tryptamine, 5-ht .
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